Inflammatiry Bowel Disease
Conditions
Interventions
Gold Standard:Endoscopy, intestinal imaging examination, Activity Index Score of Inflammatory Bowel Disease, and histopathological score.
FABP5, 
NAMPT, 
UGDH, 
LRPPRC, 
PPA1, 
miR-199a-5p, 
miR-340, 
miR- 
362-3p, 
miR-532-3p, 
miR-155.
Sponsors
Department of Gastroenterology, Affiliated Children's Hospital, Nanjing Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. It is intended to be included in the outpatient clinic of the Department of Internal Medicine or Digestive Specialist Clinic of the Children's Hospital of Nanjing Medical University from January 2019 to December 2021. The following four types of children will be selected: 1) clinical symptoms such as abdominal pain, diarrhea, bloody stools and weight loss lasted for more than 4 weeks or more than 2 times in 6 months; 2) perianal skin spasm, perianal abscess, abdomen Block or repeated oral ulcers, course >6 months; 3) growth retardation, weight loss, malnutrition, anemia, anorexia and other symptoms appear >6 months; 4) arthritis, decreased bone density, scleritis, uv Inflammation, gangrenous pyoderma, nodular erythema, fatty liver, cholangitis, course >6 months; 2. aged 1 to 14 years old children; 3. 50 children with the same age and sex ratio as a control group.
Exclusion criteria
Exclusion criteria: 1. chronic bacterial dysentery, amoebic enteritis, hemorrhagic necrotic enteritis, abdominal allergic purpura, Behcet's disease, intestinal lymphoma, intestinal tuberculosis, acute appendicitis and other diseases easily confused with inflammatory bowel disease; 2. Other systemic diseases, poor general condition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| epithelial fatty acid binding protein (FABP5);visceral adiponectin (NAMPT);uridine diphosphate glucose 6-dehydrogenase (UGDH);leucine-rich pentapeptide repeat structural egg (LRPPRC);inorganic pyrophosphate Enzyme (PPA1);microRNA;anti-Saccharomyces cerevisiae antibody (ASCA);perinuclear anti-neutrophil cytoplasmic antibodies (pANCA);SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactYang Hui
Department of Gastroenterology, Affiliated Children's Hospital, Nanjing Medical University
Outcome results
None listed