traunaric brain injury
Conditions
Interventions
pressure 
waveform, 
hemodynamics.
Gold Standard:Invasive intracranial pressure
Index test:the 
Sponsors
Ruijin Hospital North, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with acute craniocerebral injury admitted to the neurosurgical ward or intensive care unit within 48 hours after injury; 2. Moderate or severe craniocerebral injury diagnosed according to GCS score. 3. Age 18-75 years old, gender not limited; 4. Patients with acute and medium-sized craniocerebral trauma who are found to have intracranial abnormalities (intracranial hemorrhage, cerebral contusion and laceration, cerebral edema, cerebral swelling, hydrocephalus, basal cistern compression, etc.) by head CT examination, and those with indications for invasive intracranial pressure detection; 5. This study has been approved by the ethics committee of ruijin hospital affiliated to Shanghai jiaotong university school of medicine; 6. Explain the clinical trials to the patients or their families, and provide effective informed consent.
Exclusion criteria
Exclusion criteria: 1. Refractory severe intracranial hypertension; 2. The temporal window is completely closed, unable to detect blood flow signals; 3. Shock and severe compound injury; 4. Pregnant or lactating women; 5. Serious systemic diseases already existed at the time of admission: severe infection, diseases of the blood system, severe heart, liver and kidney dysfunction or patients with previous tumors; 6. Patients who died during treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| central aortic pressure waveform;invasive intracranial pressure;cerebral hemodynamics;SEN, SPE, ACC, AUC of ROC, Kappa coefficient; | — |
Countries
China
Contacts
Public ContactJunli Zuo
Ruijin Hospital North, Shanghai Jiaotong University School of Medicine
Outcome results
None listed