acute myocardial infarction with hyperuricemia
Conditions
Interventions
placebo group:placebo
Sponsors
Xiamen Cardiovascular Hospital Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) patients aged 18 to 75 years who were diagnosed as acute myocardial infarction according to symptoms of ischemic chest pain, changes in electrocardiogram and markers of myocardial injury; 2) serum uric acid greater than 7.0mg/dL with or without goutserum uric acid greater than 6mg/dL with gout; 3) the subjects can understand and comply with the protocol requirements, including regular clinical follow-up; 4) subject's legal representative is able and willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: 1) pregnant patients; 2) patients with contraindication to allopurinol, e.g. hypersensitivity to this product, severe liver and kidney dysfunction, and low blood cells; 3) the patient had received uric acid lowering treatment within 30 days prior to screening (such as allopurinol, febulatol, promethazone, etc.); 4) active peptic ulcer disease; 5) liver transaminase was more than 3 times the normal value; 6) creatinine clearance rate was less than 30ml/min; 7) the patient had a history of malignant tumor within 5 years; 8) patients with myocardial infarction 60 days before screening;
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| transient ischemic attack;Hospitalized CHF;Arrhythmias not associated with ischemia;Venous and peripheral arterial thromboembolic events; | — |
Primary
| Measure | Time frame |
|---|---|
| CV death;Nonfatal MI;Nonfatal stroke;Unstable angina with urgent coronary revascularization; | — |
Countries
China
Contacts
Public ContactZhu Weiliang
Xiamen Cardiovascular Hospital Xiamen University
Outcome results
None listed