Congenital heart disease
Conditions
Sponsors
National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Pediatric patients aged 31 days to 7 years undergo cardiac surgery with cardiopulmonary bypass including surgical repair of atrial or ventricular septal defect, atrioventricular septal defect, endocardial cushion defect or complete repair for tetralogy of Fallot, double outlet right ventricle, transposition of the great arteries, pulmonary atresia, anomalous pulmonary venous connection, anomalous origin of the left coronary artery from pulmonary artery, ect. 2. The patients are willing to participate after reading and signing an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pediatric patients undergo total cavopulmonary connection with cardiopulmonary bypass. 2. Thrombocytopenia or any other known history of bleeding disorder. 3. Thromboembolic disease: history of postoperative or spontaneous pulmonary embolism, spontaneous arterial thrombosis, or familial hypercoaguability. 4. Previous convulsion or seizure. 5. Patients with intellectual or legal disabilities. 6. Severe renal impairment (serum creatinine>3.3 mg/dL). 7. Allergy or contraindication to TXA injection or its components. 8. Currently enrolled in another perioperative interventional study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative seizure;the volume of allogeneic red blood cell transfusion after termination of cardiopulmonary bypass; | — |
Secondary
| Measure | Time frame |
|---|---|
| stroke;myocardial infarction;pulmonary embolism;deep venous thrombosis;renal dysfunction;death;the volume and exposure of allogeneic blood transfusion after termination of cardiopulmonary bypass;postoperative bleeding;the rate of reoperation;use of extracorporeal membrane oxygenation; | — |
Countries
China
Contacts
Public ContactYu Zhang
Department of Anesthesiology, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed