Mental disorder
Conditions
Interventions
Experimental group:Bifidobacterium triple live capsule
Sponsors
Second Xiangya Hospital, Central South University.
Eligibility
Sex/Gender
All
Age
16 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Subjects voluntarily participated in the trial and signed informed consent and were able to comply with the planned visits, laboratory tests and other research procedures; 2. Outpatients or inpatients of men and women aged 18 to 55 years; 3. Meet the Diagnostic and Statistical Manual of Mental Disorder-V (DSM-V) Major Depression Disorder or Bipolar Disorder Diagnostic Criteria and is reviewed by the Mini-SCID diagnostic interview tool; 4. From the signing of informed consent to the end of the trial, there will be no major changes in the diet structure.
Exclusion criteria
Exclusion criteria: 1. There are other serious somatic diseases or comorbid diseases, especially patients who are undergoing diabetes treatment or lipid-regulating therapy; patients with history of cardiovascular and cerebrovascular diseases such as coronary heart disease and cerebral infarction; 2. Meet other diagnosis of mental diseases; 3. Patients who are taking benzodiazepines daily. Patients received ECT within 6 months or need ECT in current episodes; 4. Women during pregnancy or breastfeeding, or have plan during the trial period, and women at high risk of pregnancy who have not taken any contraceptive measures; 5. There are obvious suicide attempts or behaviors; 6. Other conditions or drugs that may affect biomarkers during the trial: long-term regular administration of NSAIDs, COX-2 inhibitors, immunosuppressants, hormone drugs, interferons, chemotherapeutics, anticoagulants Etc. Malignant tumors, active autoimmune diseases, inflammatory bowel diseases, etc.; 7. Bifidobacterium triple live capsule allergy history; 8. Had a history of digestive surgery; 9. History of the use of antibiotics in the last 1 week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone density;HAMD;HAMA;Total cholesterol;Fasting plasma glucose; | — |
Countries
China
Contacts
Public ContactHaishan Wu
Second Xiangya Hospital, Central South University
Outcome results
None listed