scar
Conditions
Interventions
Group 1:The surface of the microscopic skin is underneath, and the artificial dermal support is placed on the wound surface after the scar is removed.
Group 2:The artificial dermal stent was sutured on the wound surface after the scar resection, and the autologous ultrathin skin graft was performed 21 days later.
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 60 Years
Inclusion criteria
Inclusion criteria: (1) Aged 0 to 60 years, male or female; (2) The clinical diagnosis is hypertrophic scar after burn. The burn area is: 0-6 years old >=5%, 6-18 years old >=10%, adult >=15%, and the proliferative time is June~1 year; (3) The total area of a single scar to be removed at one time is <2% (estimated by the palm method), and the target wound after the scar is expected to be between 5 cm x5 cm and 10 cm x10 cm, and the position of the scar is the limbs or the trunk; (4) Confirmed by the clinician, using other methods to treat poor results or seriously affect the function of limbs and daily life; (5) Those who agree to participate in the study and sign written informed consent.
Exclusion criteria
Exclusion criteria: (1) Proliferative scars caused by chemical burns/electric burns and other special causes such as burns, chronic wounds, and surgical incisions; keloids or atrophic scars are clearly diagnosed; (2) Severe malnutrition, albumin 38.5 degree C or white blood cells > 12 x10^9/L or marked with local inflammation; (4) Patients with severe systemic infections who require systemic antibiotic treatment; (5) Patients with tumor, radiotherapy or chemotherapy; (6) Patients with serious primary diseases such as cardiovascular, liver, kidney and blood system, and mental patients; (7) It is known that the components or other chemical structures contained in the artificial dermal scaffold have a history of allergies or allergies; (8) Pregnant or lactating women and those with birth plans; (9) Those who have participated in other clinical research within one month prior to the election; (10) Some other investigators believe that it is not appropriate to participate in clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical treatment time for wound closure after scar resection;Long-term outcome after scar removal, Scar Assessment Scale (POSAS); | — |
Countries
China
Contacts
Public ContactZhu Shihui
Department of Burns, Shanghai Changhai Hospital
Outcome results
None listed