post operative cognitive dysfunction
Conditions
Interventions
Light anesthesia group:Light anesthesia (BIS: 45-60)
Deep anesthesia group:Deep anesthesia (BIS: 35-45)
No BIS group:without BIS monitoring, regulated according to intraoperative hemodynamics
Sponsors
Shanxi Cancer Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients undergoing cervical and thoracic laparoscopic combined with esophageal cancer resection, aged > 60 years, patients who underwent preoperative examination and signed ethical consent.
Exclusion criteria
Exclusion criteria: Have a history of neurological diseases, a history of mental illness, long-term use of a large number of sedatives, severe audio-visual disorders, unable to communicate with physicians, preoperatively combined with severe hypertension, diabetes, coronary heart disease, lung function test ventilation reserves <75%, those with education level <=5 years, preoperative MMSE score <24 points.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum S100 beta protein;Mini-mental State Examination;Montreal Cognitive Assessment; | — |
Countries
China
Contacts
Public ContactXing Taotao
Shanxi Medical University
Outcome results
None listed