hypertension
Conditions
Interventions
Group 1:Oral folic acid with normal dose
Group 2:Oral folic acid with therapy dose
Sponsors
Ma'anshan People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. voluntary participation, understanding and signing of informed consent; 2. aged 18 years old male and female; 3. have a history of hypertension for more than 3 months or have been clinically diagnosed with hypertension for more than 3 months; The diagnosis of h-type hypertension met the diagnostic criteria of hypertension in the 2010 guidelines for the prevention and treatment of hypertension in China. Meet the standard of elevated blood homocysteine (10umol/L) in the guidelines for the prevention and treatment of hypertension in China 2010, or are receiving treatment to reduce homocysteine; 4. plasma HCY content 10umol/L; 5. have received standardized medication for at least 2 weeks; Standardized drug therapies include: diuretics, angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor antagonists (ARB), receptor blockers, calcium channel blockers (CCB) and other compound preparations (unless contraindicated or not tolerated, the optimal therapeutic dose should be reached).
Exclusion criteria
Exclusion criteria: 1. severe mental disorder, unable to express their willingness; 2. there are obvious other abnormal signs, laboratory tests and clinical diseases, which, according to the judgment of the researcher, are not suitable for the researcher; 3. the researcher could not judge the long-term follow-up; 4. for patients with uncontrolled hypertension, systolic blood pressure 180/mmHg and/or diastolic blood pressure 110mmHg; Systolic blood pressure <90mmHg and/or diastolic blood pressure <60mmHg; 5. participate in clinical research of other drugs within 1 month; 6. women who are pregnant or preparing for pregnancy and lactation; 7. allergy, or known allergy to therapeutic drugs; 8. according to the judgment of the researcher, the patients cannot complete this study or cannot comply with the requirements of this study (due to management reasons or other reasons).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HCY;Carotid plaque score; | — |
Secondary
| Measure | Time frame |
|---|---|
| systolic pressure;diastolic pressure;Biochemical all items;Heart colour to exceed; | — |
Countries
China
Contacts
Public ContactHang Wu
Ma'anshan People's Hospital
Outcome results
None listed