Osteoarthritis of the knee
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) patients requiring unilateral initial TKA surgery due to severe knee osteoarthritis; (2) aged 40 to 80 years; (3) body mass index was 20~35 kg/m2; (4) the American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) is I ~ III level.
Exclusion criteria
Exclusion criteria: (1) allergic to anesthetic drugs and sulfa; (2) there were more than moderate intraoperative knee malformations (pronation and flexion malformations) and joint stiffness; (3) alcoholic or long-term opioid users; (4) language impairment and inability to perform pain numerical scales (NRS); (5) surgical limb neuropathy; (6) mental patients; (7) patients with previous gastrointestinal ulcer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative dosage of remedial morphine hydrochloride;Time of first postoperative analgesia;VAS pain score;Range of knee motion;Quadriceps strength;Daily walking distance;Complication rate; | — |
Countries
China
Contacts
West China Hospital, Sichuan University