sepsis or septic shock
Conditions
Interventions
Experimental group:resuscitation strategy aimed to optimize the left ventricular-arterial coupling
Control group:usual resuscitation strategy
Sponsors
HwaMei Hospital, University Of Chinese Academy of Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. the left ventricular-arterial is uncoupling (VAC > 1.36) at time of sepsis or septic shock diagnosis in patients with sepsis or septic shock, which defined by 2016 SSC guidelines; 2. Aged =18 years; 3. Written informed consent could be obtained from the patients or their legal representatives.
Exclusion criteria
Exclusion criteria: 1. left ventricular-arterial coupling at time of sepsis or septic shock diagnosis; 2. acute myocardial infarction; 3. aortic valve disease; 4. postoperative cardiac surgery; 5. have a history of pulmonary hypertension; 6. complicated with cardiac dysfunction before septic shock; 7. Patients who are expected to die within 6 hours after sepsis/septic shock diagnosis; 8. are failure to undergo transthoracic echocardiography orobtain satisfactory cardiac ultrasound images; 9. There is a contraindication to use of levosimendan or dobutamine (such as heart mechanical obstruction,etc).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU mortality;in-hospital mortality;duration of ICU stay;duration of in-hospital stay;duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactZhou Xiaoyang
HwaMei Hospital, University Of Chinese Academy of Sciences
Outcome results
None listed