Acute pancreatitis
Conditions
Interventions
Group A:Endoscopic transluminal necrosectomy
Group B:percutaneous flexible endoscopic necrosectomy
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged =18 and <85 years; 2. Suspected or confirmed infection of pancreatic necrosis and /or peripancreatic necrosis; 3. The patient has the technical conditions of Endoscopic transluminal drainage and percutaneous catheter drainage.
Exclusion criteria
Exclusion criteria: 1. Severe coagulation dysfunction and other endoscopic contraindications. 2. Pregnant or lactating women; 3. Patients underwent interventional therapy (surgical, endoscopic or percutaneous drainage) for pancreatic necrosis or peripancreatic necrosis before grouping. 4. Indications for emergency laparotomy include intestinal ischemic necrosis, bleeding, perforation of visceral organs, and abdominal compartment syndrome which is difficult to be corrected by conservative treatment. 5. Those who refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality;New-onset organ failure;Enteral-pancreatic cutaneous fistula;Visceral perforation;Intra-abdominal bleeding,;Enterocutaneous fistula;Pancreatic-cutaneous fistula; | — |
Secondary
| Measure | Time frame |
|---|---|
| Exocrine insufficiency;New-onset diabetes;Wound infections;Procedure-related adverse events;Disease-related adverse events;Drainage procedures;Necrosectomies;Additional interventions, endoscopy or surgical interventions are required;Days in ICU within 6 months of randomisation;Days in hospital within 6 months of randomisation;Post-procedural SIRS;Readmissions; | — |
Countries
China
Contacts
Public ContactNonghua Lv
The First Affiliated Hospital of Nanchang University
Outcome results
None listed