Intraoperative ulinastatin's effect on endothelial glycocalyx layer in Periampullary Carcinoma Patients Undergoing Traditional Whipple Procedure

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900024004

Enrollment

Unknown

Registered

2019-06-22

Start date

2015-01-02

Completion date

Unknown

Last updated

2019-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the intraoperative dysfunction of vascular barrier function

Interventions

Experimental group:ulinastatin

Control group:Normal saline

Eligibility

Sex/Gender

All

Age

35 Years to 75 Years

Inclusion criteria

Inclusion criteria: Pancreatic cancer patients undergoing Whipple procedure; ASA I-III; Aged 18-75 years.

Exclusion criteria

Exclusion criteria: body mass index >35 kg/m2, cardiac failure (New York Heart Association class >II), obvious coagulation disorders, severe pulmonary or systemic infections, treatment with immunosuppressant drugs in the 8 weeks before surgery, and tobacco/alcohol abuse.

Design outcomes

Primary

Measure	Time frame
plasma albumin;C-reactive protein;syndecan-1;iL-6;ICAM-1;VCAM-1;thrombomodulin;	—

Countries

China

Contacts

Public ContactYan Wu

Beijing Chaoyang Hospital

yhanwu@sina.com+86 13651077828

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026