To explore the changes of the human immune system in the development of neurodegenerative diseases (Alzheimer's disease, Parkinson's disease) and their mutual network regulation

Single-Cell Transcriptomic Analysis of Peripheral Blood Mononuclear Cells in Alzheimer's Disease

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900023975

Enrollment

Unknown

Registered

2019-06-20

Start date

2017-09-30

Completion date

Unknown

Last updated

2019-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease, Parkinson's disease

Interventions

Case vs control:No

Eligibility

Sex/Gender

All

Age

59 Years to 98 Years

Inclusion criteria

Inclusion criteria: Patient inclusion criteria: 1. Clinically diagnosed patients with neurodegeneration, neurogenetic and dyskinesia; 2. The subject volunteered and signed an informed consent form. The control group included the criteria: 1. Patients with other diseases other than neurodegeneration, neurogenetics, and dyskinesia (control for cerebrospinal fluid specimen studies) 2. Normal healthy controls (for control of blood specimen studies) 3. Subjects voluntarily and signed informed consent.

Exclusion criteria

Exclusion criteria: Patient exclusion criteria: 1. Meet the inclusion criteria, but suffer from diseases such as the immune system, endocrine system, tumor, mental disorders, etc. 2. The patient refused to cooperate. Exclusion criteria for the control group: 1. Patients who meet the inclusion criteria but have diseases such as the immune system, endocrine system, tumor, and mental disorders, affecting the study; 2. The patient refused to cooperate.

Design outcomes

Primary

Measure	Time frame
Single-Cell Transcriptomic Analysis;Routine blood test;blood bio-chemistry checking;electroencephalogram;Magnetic Resonance Imaging;Computed Tomography;Polymerase Chain Reaction;	—

Secondary

Measure	Time frame
The related situation of the patients of follow-up;	—

Countries

China

Contacts

Public ContactXiong Liulin

West China Hospital, Sichuan University

499465010@qq.com+86 18227648803

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026