Elevated blood flow resistance in uterine arteries
Conditions
Interventions
Group 1:Isosorbide dinitrate, intravaginal administration, 1 table, b.i.d.+ aspirin, oral, 25mg t.i.d.
Group 2:aspirin, oral, 25mg t.i.d.
Sponsors
Ruijin Hospital School of Medicine, Shanghai Jiaotong University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Patients recruited were 20-35 years old, using hormone replacement therapy to prepare the endometrium and receiving frozen embryo transfer for the frst time, without taking any drugs or udergoing surgery on uerus or ovary 1 month before initiating the cycle.
Exclusion criteria
Exclusion criteria: Women with uterine fibroids, endometriosis, adenomyosis, endometrial polyps, intrauterine adhesions, repeated implantation failure, thyroid dysfunction, insulin resistance and other endocrine diseases, known drug contraindications were excluded.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Implantation rate was observed 11 days after transplantation;Multitle-gestation pregnancy rate observed 25 days after transplantation;Rate of first trimester abortion oberserved before 12 weeks of gestation;Rate of late abortion oberserved during 12-28 weeks of gestation;Rate of preterm birth observed during the 28-36 weeks of gestation;Rate of adverse event;Rate of cycle cancellation; | — |
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate observed 25 days after transplantation; | — |
Countries
China
Contacts
Public ContactBufang Xu
Ruijin Hospital School of Medicine, Shanghai Jiaotong University
Outcome results
None listed