Uveitis
Conditions
Interventions
Liver function normal/abnormal: Anti-HBc negative:immunosuppressive therapy
Liver function normal/abnormal: Anti-HBc positive, HBsAg negative:immunosuppressive therapy
Liver function normal/abnormal: both anti-HBc and HBsAg are positive:immunosuppressive therapy
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged = 18 years; 2. Non-infectious intermediate uveitis, posterior uveitis, and panuveitis in unilateral or bilateral eyes; 3. Individuals qualified in health condition according to medical history, laboratory data, physical examination, chest x-rays, and 12-lead electrocardiogram results taken during screening; 4. Those who provide written informed consent; 5. Individuals are willing and able to follow visiting plans, treatment plans, laboratory examinations, and other study procedures.
Exclusion criteria
Exclusion criteria: 1. Simple anterior uveitis; 2. Hepatitis C, hepatitis D, alcoholic liver disease, primary biliary cirrhosis, or autoimmune liver disease; 3. Confirmed or suspected infectious uveitis, including but not limited to tuberculosis, cytomegalovirus, Lyme disease, toxoplasmosis, infectious uveitis caused by Human T-lymphotropic virus 1, herpes zoster virus or herpes simplex virus; 4. History of moderate to severe congestive heart failure (New York Heart Association classification III or IV), recent cerebrovascular accidents; 5. Severe kidney disease, chronic renal failure, or dialysis treatment; 6. Severe liver disease, liver fibrosis; 7. Severe pulmonary disease, grade 3 or 4 (COPD or oxygen-dependent emphysema); 8. Masquerade syndrome or malignant tumor, such as eye lymphoma, leukemia, choroid melanoma, etc.; 9. Individuals with a history of malignant tumors in other tissues and organs, who have received or are undergoing treatment for malignant tumors, or whose remission period of malignant tumors is less than 5 years; 10. HIV positive individuals during screening; 11. Individuals with chronic recurrent infection and active tuberculosis may have a history of invasive infection at the time of screening (e.g., listeriosis, histoplasmosis); 12. Receiving anti-TB treatment; 13. Addicted to drugs, alcohol or psychotropic substances; 14. Severe mental disorders (e.g., schizophrenia, treatment-resistant bipolar disorder, current severe depression); 15. Women of reproductive age who are pregnant or lactating and who are unwilling or unable to use the acceptable contraceptive methods prescribed in the program during the study period; 16. For any reason, the researchers do not consider this study suitable for individuals.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBV serology;HBV DNA quantification;liver function; | — |
Countries
China
Contacts
Public ContactPeizeng Yang
Chongqing Medical University
Outcome results
None listed