Prospective study for the effect of abdominal hypertension on intestinal mucosal barrier injury during laparoscopic surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900023936

Enrollment

Unknown

Registered

2019-06-19

Start date

2017-09-01

Completion date

Unknown

Last updated

2019-07-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intestinal mucosal barrier injury

Interventions

1:Increase pneumoperitoneum pressure

2:none

3:Reduce pneumoperitoneum pressure

Eligibility

Sex/Gender

All

Age

20 Years to 81 Years

Inclusion criteria

Inclusion criteria: (1) age range from 20 to 81 years; (2) the American society of anesthesiologists (ASA) grade I~ II; (3) the imaging examination (color ultrasound, CT or MRI) was clearly cholecystolithiasis; (4) the patient agreed to undergo laparoscopic cholecystectomy.

Exclusion criteria

Exclusion criteria: (1) contraindication of laparoscopic surgery (such as extensive intraperitoneal adhesion, etc.); (2) emergency surgery; (3) preoperatively complicated with obvious intestinal obstruction or intestinal paralysis; (4) preoperative systemic inflammatory response syndrome and other diseases; (5) conversion to open surgery; (6) persistent uncorrected water electrolyte disturbance (e.g., hypokalemia, hypomagnesemia, etc ).

Design outcomes

Primary

Measure	Time frame
serum tumor necrosis factor-alpha;interleukin-1;blood d-lactic acid;endotoxin levels;plasma diamine oxidase (DAO) activity;	—

Secondary

Measure	Time frame
operation time;duration of CO2 pneumoperitoneum;intraoperative blood loss;	—

Countries

China

Contacts

Public ContactYang Yong

The First People's Hospital of Shuangliu District, Chengdu, Sichuan

88499353@qq.com+86 13308070645

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026