Transcranial direct current stimulation combined with mirror neurons rehabilitation training system in the treatment of patients with disorder of consciousness after Severe Craniocerebral Injury

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900023907

Enrollment

Unknown

Registered

2019-06-17

Start date

2020-02-01

Completion date

Unknown

Last updated

2019-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with disorder of consciousness after Severe Craniocerebral Injury

Interventions

Conventional + sham stimulation tDCS group:Conventional + sham stimulation tDCS

Conventional + anode tDCS group:Conventional + anode tDCS

Conventional + MNST group:Conventional + MNST

Conventional + anode tDCS+MNST group:Conventional + anode tDCS+MNST

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Craniocerebral injury was the only factor causing coma, and craniocerebral imaging (CT or MRI) confirmed that the left frontal lobe brain area was not completely damaged; (2) The primary condition is stable, stable vital signs, no hydrocephalus, no severe brain atrophy or severe brainstem lesions; (3) GCS score 4-8 points, and can open eyes; (4) Aged 18-60 years; (5) Within 3 months after onset; (6) The patient's family informed and agreed; (7) Before the clinical trial did not receive transcranial direct current therapy and mirror neuron rehabilitation training.

Exclusion criteria

Exclusion criteria: (1) Patients who failed to complete the 8-week course of treatment as planned; (2) In the course of treatment of serious complications in patients with termination of treatment; (3) Patients who fall off naturally (including those who are transferred to hospital, transferred to hospital, family members who refuse treatment during the course of treatment, patients whose condition changes and cannot continue relevant treatment, and patients who die); (4) Serious heart disease, epilepsy; (5) Placement of electronic devices (such as pacemakers), intracranial or therapeutic areas with metal parts; (6) Local skin injury or inflammatory reaction, stimulate regional pain hypersensitivity; (7) Vision or hearing impairment, eye infectious diseases.

Design outcomes

Primary

Measure	Time frame
Glasgow Coma Scale;JFK coma recovery scale;Four coma rating scale;Brainstem evoked potential;Somatosensory evoked potential;	—

Secondary

Measure	Time frame
Improved Barthel index;Functional mri of the brain;	—

Countries

China

Contacts

Public ContactHaixia Feng

Rehabilitation Central Hospital of Gansu Province

119242826@qq.com+86 13893677145

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026