Congenital heart disease
Conditions
Interventions
Group 3:Paravertebral block combined with dexmedetomidine
Group 4:Dexmedetomidine
Group 5:Postoperative dexmedetomidine was added
Sponsors
Guangzhou Women and Children Medical Center
Eligibility
Sex/Gender
All
Age
0.1 Years to 3 Years
Inclusion criteria
Inclusion criteria: 1) Aged one month to three years, weight 5 kg to 20 kg; 2) ASA I-III; 3) Precocious heart disease surgical risk rating: RACHS level 1-4(RACHS level 3-4 should be cautious); 4) Surgical malformation treatment satisfaction(TEE evaluation anatomy and circulation); 5) Assessment of Breathing Cycle Function at Stop Time: Blood gas: electrolytes; Lung ventilation index ventilation index(carbon dioxide partial pressure, oxygen partial pressure, oxygenation index); P-V ring assessment of lung compliance(especially in preoperative pneumonia); Direct pulmonary arterial pressure measurement(especially in children with preoperative pulmonary hypertension); Circulatory status assessment(application of vasoactive drugs, systolic pressure, mean pressure, pulse pressure difference, EF value, myocardial surface color and myocardial contraction state, pacemaker adjustable arrhythmia, lactic acid value); 6) Extraction time assessment of respiratory circulation function: Breathing(frequency, Tidal volume, oxygen saturation, lung ventilation index); Circulation(application of vascular active drugs, systolic pressure, mean pressure, pulse pressure difference, TEE) Blood gas(acid-base electrolytes, lactic acid); pupil; Urine volume and color.
Exclusion criteria
Exclusion criteria: 1) ASA Level 4-5, RACHS Level 5-6 2) Preoperative treatment for heart failure pneumonia 3) Liver and kidney diseases, with clotting disorders; 4) Poor premature infants 5) Unsatisfactory treatment of surgical deformities Multiple drug support, hemodynamic instability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum cortisol;Insulin;blood glucose;norepinephrine(NE);epinephrine(E); | — |
Secondary
| Measure | Time frame |
|---|---|
| immune factor;Vital signs;Postoperative pain score;Dosage of analgesic drugs;Changes in body temperature;Coagulation function;Inflammatory factor;Operation time;Extracorporeal circulation time;Length of stay;Hospitalization expenses;Tracheal extubation time; | — |
Countries
China
Contacts
Public ContactXingrong Song
Anesthesiology Department, Guangzhou Women and Children Medical Center
Outcome results
None listed