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A randomized, controlled study for the effects of desflurane or propofol on postoperative pulmonary function and inflammatory response during one-lung ventilation in thoracic surgery

A randomized, controlled study for the effects of desflurane or propofol on postoperative pulmonary function and inflammatory response during one-lung ventilation in thoracic surgery

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900023886
Enrollment
Unknown
Registered
2019-06-15
Start date
2019-07-01
Completion date
Unknown
Last updated
2019-06-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

thoracic surgery

Interventions

Desflurane Group:desflurane
Propofol Group:propofol

Sponsors

Shanghai Jiaotong University School of Medicine, Renji Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1)Aged 20 to 60 years; 2)ASA I~II; 3)Elective surgery undergo general anesthesia; 4)Surgical time= 2 hours; 5)Fully cooperate to perform spirometry. 6)Informed consented and volunteered to participate.

Exclusion criteria

Exclusion criteria: 1)Smoking; 2)Immune dysfunction (history of a common autoimmune disease, such as type-1 diabetes or rheumatoid arthritis); 3)Abnormal lung function (forced expiratory volume in 1 s 50% of predicted value, maximal oxygen consumption 35 kg/m2.

Design outcomes

Primary

MeasureTime frame
postoperative pulmonary function;postoperative inflammatory response;—

Countries

China

Contacts

Public ContactZhenhong Wang

South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University

rjnymzksci@163.com+86 18621625707

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026