Hypopituitarism
Conditions
Interventions
Usual treatment group:Insulin dosage in ITT was calculated at 0.15U/kg body weight
Experimental group:Insulin dosage in ITT will be calculated at ? U/kg body weight (? = - 0.034+ 0.000176×AUCINS+ 0.01×BMI)
Sponsors
Ruijin Hospital North Campus, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 50 male or female; 2. Diagnosed as congenital GHD (or congenital hypopituitarism) in childhood or in line with the clinical symptoms and signs related to congenital GHD; 3. Evidence of clinical symptoms and signs related to GHD in patients with previous hypothalamic-pituitary diseases (secretory, craniocerebral structure or genetic abnormality); 4. Patients who have received craniocerebral tumor treatment (including surgery and radiotherapy); 5. Patients who participated in the experiment after the operation of sellar region or pituitary tumor were all more than 6 months after the operation; 6. Voluntarily participate and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of malignant tumor; 2) Patients with diabetes or have used hypoglycemic drugs; 3) Patients with intracranial hypertension; 4) Patients with severe liver and kidney dysfunction; 5) Patients with a history of heart disease, including ischemic heart disease, fatal arrhythmia, and cardiac dysfunction; 6) Patients with a history of epilepsy; 7) Pregnant and lactating women; 8) Patients with severe hypertension, blood pressure > 180/110 mmHg (1 mmHg = 0.133 kPa); 9) Patients undergoing antidepressant therapy, immunosuppressive therapy, chemotherapy and radiotherapy (except for pituitary diseases); 10) Psychopaths.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ratio of developed hypoglycemia with one dose of insulin in ITT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lowest blood glucose in ITT;The ratio of severe hypoglycemia in ITT; | — |
Countries
China
Contacts
Public ContactZhang Yuwen
Ruijin Hospital North Campus, Shanghai Jiaotong University School of Medicine
Outcome results
None listed