Clinical and basic study for intra-coronary precision reverse thrombolysis combined with PCI in the treatment of acute ST-segment elevation myocardial infarction

Conditions

Acute myocardial infarction

Mingzhi Shen, Jihang Wang, Dongyun Li, Xinger Zhou, Yuting Guo et al. (12 authors)

Frontiers in Cardiovascular Medicine2022-09-15

10.3389/fcvm.2022.928695

Intracoronary artery retrograde thrombolysis for ST-segment elevation myocardial infarction with a tortuous coronary artery: A case report and review of the literature

Mingzhi Shen, Haihui Lu, Yichao Liao, Jian Wang, Yi Guo et al. (13 authors)

Frontiers in Cardiovascular Medicine2022-08-041 citations

10.3389/fcvm.2022.934489

Intracoronary artery retrograde thrombolysis combined with percutaneous coronary interventions for ST-segment elevation myocardial infarction complicated with diabetes mellitus: A case report and literature review

Mingzhi Shen, Yichao Liao, Jian Wang, Xinger Zhou, Yuting Guo et al. (14 authors)

Frontiers in Cardiovascular Medicine2022-07-221 citations

10.3389/fcvm.2022.962127

Interventions

group1:Thrombosis or PTCA+PCI

group2:CART+PCI

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. diagnosis of STEMI, onset time less than 12 hours, coronary angiography confirmed thromboembolic occlusion, in line with the direct PCI indication recommended by the ACC/AHA STEMI treatment guidelines; 2. ischemic chest pain lasts for = 30min, and nitroglycerin is not relieved; 3. Electrocardiogram examination at least 2 adjacent chest lead ST segment elevation = 0.2mv or II, III, avF lead in at least 2 lead ST segment elevation = 0.1mv; 4. contrast distance onset = 12h; 5. The angiography showed that the blood vessel was a completely occluded lesion and a hemostatic load was severe.

Exclusion criteria

Exclusion criteria: (1) known obvious bleeding tendency; (2) active digestive ulcers; (3) Surgery or traumatic operation within 8 weeks before acute myocardial infarction; (4) severe trauma occurred within 1 week before acute myocardial infarction; (5) Infective endocarditis; (7) liver or kidney dysfunction; (8) pregnancy; (9) Uncontrolled hypertension (>180/100mmHg); (10) Hemorrhagic stroke occurred at any time in the past, and ischemic stroke occurred within 3 months.

Design outcomes

Primary

Measure	Time frame
Three-stage blood flow ratio after occlusive artery surgery;Intraoperatively Corrected TIMI Frame Blood Flow Grading;Incidence of slow blood flow and no reflow;Improvement of clinical symptoms in patients;Rate and time of ST segment depression > 70% after operation;Quantitative changes of myocardial enzymes and markers of myocardial injury in one week (area under peak curve);Incidence of perioperative massive hemorrhage;Thrombocytopenia rate;Changes of plasma fibrinogen and D-dimer;Serious adverse cardiac events (death, acute heart failure, reinfarction) during perioperative period (48 hours after interventional therapy) and 30 days after operation;	—

Measure

Time frame

Three-stage blood flow ratio after occlusive artery surgery;Intraoperatively Corrected TIMI Frame Blood Flow Grading;Incidence of slow blood flow and no reflow;Improvement of clinical symptoms in patients;Rate and time of ST segment depression > 70% after operation;Quantitative changes of myocardial enzymes and markers of myocardial injury in one week (area under peak curve);Incidence of perioperative massive hemorrhage;Thrombocytopenia rate;Changes of plasma fibrinogen and D-dimer;Serious adverse cardiac events (death, acute heart failure, reinfarction) during perioperative period (48 hours after interventional therapy) and 30 days after operation;

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Countries

China

Contacts

Public ContactTian Jinwen

The General Hospital of the People's Liberation Army (PLAGH)

tjwsqr.2000@163.com+86 13911411841

Outcome results

None listed