Huntington disease
Conditions
Interventions
HD-sham-DBS group:sham-DBS
HD-DBS group:DBS
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
30 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged = 30 years; 2. 39 or more CAG repeats of HTT gene; 3. Meet HD diagnostic criteria based on genetic testing; 4. The major complaint is chorea; 5. Mini–Mental State Examination (MMSE) score > 25; 6. Unified Huntington's Disease Rating Scale (UHDRS) =20; 7. Before recruitment, stable medication having been used for at least 3 months, and no plan to change medication within 12 months after randomization; 8. Agree to be enrolled in this trial.
Exclusion criteria
Exclusion criteria: 1. Chorea caused by other diseases; 2. Concurrent or previously had other neurological disorders (such as stroke, optic neuromyelitis, Parkinson's disease, epilepsy, intracranial tumors, etc.); 3. Severe psychiatric disease, such as schizophrenia, bipolar disorder, major depression and paralysis, etc.; 4. Unstable condition or severe heart, lung, liver, kidney, and hematopoietic diseases; 5. Have a history of cancer unless it has been cured or does not require treatment for the next 5 years; 6. Contraindications of MRI scan.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Mental Behavior Rating Scale;EQ-5D;MRI data;LFP; | — |
Primary
| Measure | Time frame |
|---|---|
| UHDRS; | — |
Countries
China
Contacts
Public ContactZhang Jianguo
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed