Medulloblastoma
Conditions
Interventions
Case series:endostar plus radiotherapy
Sponsors
Army Characteristic Medical Center (Daping Hospital)
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Aged 6 -18 years old; 2. KPS score (=60); 3. Children with recurrent medulloblastoma (WHO IV grade) confirmed by imaging examination or pathological examination had complete molecular pathological results and recepted surgical resection; 4. Leukocyte count (=4.0 *10^9/L) and platelet count (=100 *10^9/L); 5. Blood urea nitrogen and creatinine < 1.5 times value of the upper limit of normal laboratory; 6. Blood total bilirubin and direct bilirubin < 1.5 times value of the upper limit of normal laboratory; 7. ALT and AST < 1.5 times value of the upper limit of normal laboratory; 8. Patients who were previously healthy and had no serious allergic reaction to biological agents;Patients or their legal guardians voluntarily participate in the group with good compliance, and cooperate with the experimental observation and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. patients who have received other antiangiogenic drugs recently; 2. Patients with severe compression of brainstem, hydrocephalus and other nervous system diseases, which need urgent treatment; 3. Patients with acute or chronic infectious diseases or infectious diseases; 4. Patients with original heart disease, cardiac insufficiency or abnormal electrocardiogram; 5. Patients with uncontrollable mental illness, mental disorder and poor compliance; 6. Patients who can not receive enhanced magnetic resonance scans; 7. Patients who also participated in other clinical trials; 8. patients who researchers believe that should not participate in the trial,such as having active bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Curative effect evaluation; | — |
Countries
China
Contacts
Public ContactGeng Mingying
Army Characteristic Medical Center (Daping Hospital)
Outcome results
None listed