Helicobacter pylori infection
Conditions
Interventions
Group 1:quadruple therapy containing cefuroxime and minocycline
Group 2:quadruple therapy containing cefuroxime and metronidazole
Group 3:quadruple therapy containing minocycline and metronidazole
Sponsors
Department of Gastroenterology, Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Consecutive patients with dyspepsia who are referred to the Peking University Third Hospital; 2. Urea breath test positive or gastroscopic mucosal biopsy revealed double positive staining of Hp RUT and Warthin-Starry; 3. Aged 18 years and elder man or woman; 4. penicillin allergy; 5. Willing and available for participation this study.
Exclusion criteria
Exclusion criteria: 1. Received treatment for Hp infection; Taking any drug which could influence the study results such as PPI, H2-receptor blockers, bismuth salts and antibiotics in the previous 4 weeks; 2. Gastrointestinal malignancy; 3. Zollinger-Ellison syndrome; 4. Previous gastric and esophageal surgeries; 5. Severe concomitant cardiovascular, respiratory, renal, hepatic, hematological, neurological, endocrine or psychiatric diseases; 6. History of allergy to any of the drugs used in the study; 7. Pregnancy or lactation; 8. Any other clinically significant medical condition that could increase risk of side effects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Compliance;safety; | — |
Countries
China
Contacts
Public ContactLiya ZHOU
Peking University Third Hospital
Outcome results
None listed