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Impact of serotonin transporter gene on rTMS augmentation of SSRIs for obsessive compulsive disorder

Association between transporter gene polymorphism and efficacy of fluoxetine combined with rTMS in the treatment of obsessive-compulsive disorder

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900023641
Enrollment
Unknown
Registered
2019-06-05
Start date
2016-12-01
Completion date
Unknown
Last updated
2019-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-compulsive disorder

Interventions

Active rTMS group:rTMS combined with SSRI treatment
Control group:Simulated stimulate treatment

Sponsors

Wuxi Mental Health Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) diagnosis of current OCD by a psychiatrist in accordance with DSM-IV on the basis of structured clinical interview for DSM (SCID); (2) patients were willing and able to consent to the study on the basis of their ability to provide a spontaneous narrative description of its key elements; (3) aged between 18 and 65 years.

Exclusion criteria

Exclusion criteria: (1) patient used medication; (2) patient had metal implants; (3) female participants were pregnant, breast-feeding, or intended to become pregnant during the period of the study; (4) there was a history of DSM-IV substance-dependence in the past 6 months; (5) acute suicidality; (6) patients experienced severe adverse effects during or after the treatment or if the patient withdrew from the study for any reason; (7) seizures or further neurological disorders or major medical issues were reported or recorded; (8) With co-morbid psychiatric disorders; (9) currently use alcohol and other drug.

Design outcomes

Primary

MeasureTime frame
Yale-Brown Obsessive Compulsive Scale;

Secondary

MeasureTime frame
Hamilton Depression Rating Scale;

Contacts

Public ContactGuoqiang Wang

Wuxi Mental Health Center

wuximhcguoqiang@163.com+86 13358118972

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026