hypertriglyceridemic pancreatitis
Conditions
Interventions
Group A:Low molecular weight heparin combined with insulin
Group B:insulin
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 85 years; 2. Meet the diagnostic criteria of acute pancreatitis; 3. Acute pancreatitis onset =11.30 mmol/L and <40 mmol/L; 5. Signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. The patient had biliary causes at the same time, a biliary etiology was defined as the presence of dilated CBD, or two of the following three laboratory abnormalities: (1) serum bilirubin concentration > 1.9 mg/dL; (2) alanine aminotransferase (ALT) activity > 100 U/L with an ALT activity higher than the aspartate aminotransferase (AST) activity; and (3) alkaline phosphatase activity > 195 U/L with a ?-glutamyltransferase (GGT) activity > 45 U/L. 2. Patient has a history of over 5 years of heavy alcohol consumption (> 50 g per day). 3. Pregnant or lactating women; 4. Disseminated intravascular coagulation, or active bleeding; 5. Those who are allergic to heparin or insulin; 6. Those who had received lipid-lowering therapy, plasma exchange or hemofiltration before admission;Or patients who require blood purification treatment due to acute renal failure 7. Cardiopulmonary resuscitation due to cardiac arrest; 8. Patients with irreversible organ failure or other critical manifestations who are expected to die within 24 hours, including patients with severe ARDS requires in vitro life support (PEEP>10 cm H2O, FiO2=100%, FiO2/ PO2<60); severe systemic circulatory failure, (under full-fluid resuscitation and norepinephrine usage at a dose of 25 ug/ min, with a systolic blood pressure <90mm Hg and serum pH values <7.0); Severe coma without sedation drugs and who had a Glasgow score=3 points. 9. Advanced malignant tumors, immunodeficiency disorders, and Patients who required regular hemodialysis for a preexisting chronic kidney disease. 10. Persons whose conscious and behavioral abilities are partially or totally limited and unable to make decisions independently.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A composite of new-onset organ failure and mortality;Vein thrombosis;Sinistral portal hypertension;Abdominal compartment syndrome;Cerebral hemorrhage;The demand for mechanical ventilation;Renal replacement therapy;Percutaneous drainage of ascites;Drainage of pancreatic necrosis;Endoscopic debridement for pancreatic necrosis;Vascular interventional therapy;ICU stay;Length of hospital stay, days;Hospital costs;New-onset bleeding;Rebound of serum TG;Drugs-related adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| New-onset organ failure;Mortality;Time to achieve the TG goal of < 5·65 mmol/L, days;systemic inflammatory response syndrome (SIRS);Necrotizing pancreatitis;Infected pancreatic necrosis;Sepsis;Pulmonary infection;Pseudoaneurysm; | — |
Countries
China
Contacts
Public ContactNonghua Lv
The First Affiliated Hospital of Nanchang University
Outcome results
None listed