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A randomized controlled trial for heparin and protamine administration strategies in cardiopulmonary bypass between traditional regimen and new mathematical model

A randomized controlled trial for heparin and protamine administration strategies in cardiopulmonary bypass between traditional regimen and new mathematical model

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900023623
Enrollment
Unknown
Registered
2019-06-04
Start date
2019-06-04
Completion date
Unknown
Last updated
2019-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiopulmonary bypass

Interventions

Traditional protocol group:Heparin and protamine were given in CPB according to the traditional protocol
New protocol group:Heparin and protamine were given in CPB according to new protocol

Sponsors

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age 18-79, ASA Class II-III; 2. Hospitalized patients undergoing elective cardiopulmonary bypass surgery in our medical institution; 3. BMI 18.5 to 35; 4. Consent to participate in the experiment and informed consent has been signed.

Exclusion criteria

Exclusion criteria: 1. Preoperative heparin therapy, past history of coagulation system diseases and heparin allergy; 2. Heart transplantation; 3. Definite liver injury (Bilirubin > 20 mmol/L, INR > 2.0); 4. Definite renal impairment (GFR < 30 ml/min/1.73 m2).

Design outcomes

Primary

MeasureTime frame
Activated coagulation time;—

Countries

China

Contacts

Public ContactChang Zhu

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

changzhu@hust.edu.cn+86 13627131570

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026