Skip to content

Efficacy of dexamethasone combined with metronidazole and gentamicin in reducing inflammatory response after mandibular impacted third molar extraction

Efficacy of dexamethasone combined with metronidazole and gentamicin in reducing inflammatory response after mandibular impacted third molar extraction

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900023613
Enrollment
Unknown
Registered
2019-06-04
Start date
2019-06-17
Completion date
Unknown
Last updated
2019-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mandibular impacted third molar

Interventions

experimental group1:Dexamethasone, metronidazole and gentamicin rinse
experimental group2:Dexamethasone and saline rinse
experimental group3:Saline, metronidazole and gentamicin rinse
control group:Saline rinse

Sponsors

The Sixth Affiliated Hospital of Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-30 years; 2. Volunteered to participate in the study and have signed the informed consent; 3. The mandibular third molar belongs to the Pell and Gregory class II position B; 4. Be able to communicate well with researchers and comply with the requirements of the whole study.

Exclusion criteria

Exclusion criteria: 1. Use anti-inflammatory or analgesics during within 15 days before enrollment; 2. Allergic to drugs or other substances used in the study; 3. pregnant or lactating women; 4. Abnormal blood routine; 5. Coagulation dysfunction or previous use of anticoagulant drugs within 1 month; 6. Liver and kidney dysfunction; 7. Mentally ill people cannot sign informed consent forms; 8. Due to poor compliance, the researchers considered who inappropriate to continue to participate in this clinical trial.

Design outcomes

Primary

MeasureTime frame
Pain visual analogue scale;Swelling assessment;Trismus;

Countries

China

Contacts

Public ContactRen Jie

The Sixth Affiliated Hospital of Sun Yat-Sen University

renjiehxky@163.com+86 18620064680

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026