trauma, degenerative disease or deformity of the spine
Conditions
Interventions
A:one bolus of 20 mg/kg IV-TXA prior to skin incision, 5 boluses of 10mg/kg IV-TXA 3, 6, 12, 18, 24 hours later
or combine the topical use of TXA
B:the same volume of Physiological saline
Sponsors
Hong Hui Hospital, Xi'an Jiaotong University College of Medicine
Eligibility
Sex/Gender
All
Age
5 Years to 90 Years
Inclusion criteria
Inclusion criteria: All patients, aged 18 years or older, who were scheduled to haveposterior spinal surgery for trauma, degenerative disease or deformity of the spine will be considered eligible for inclusion.
Exclusion criteria
Exclusion criteria: With anemia (<120 g/L for female, <130 g/L for male), cardiovascular problems (history of myocardial infraction, angina, and atrial fibrillation), cerebrovascular conditions (history of previous stroke), thromboembolic disorders (history of deep-vein thrombosis (DVT) or pulmonary embolism (PE)), clotting disorders, known allergy to TXA, Patients with high blood coagulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative blood loss;Perioperative blood transfusion;The operation time;Hemoglobin;thrombosis;wound complications;Oswestry disability index;the MOS item short from health survey, SF-36;Length of hospital stay;fibrinolysis index (D-Dimer, FDP);The amount of albumin; | — |
Countries
China
Contacts
Public ContactXiaowei Yang
Hong Hui Hospital, Xi'an Jiaotong University College of Medicine
Outcome results
None listed