Congenital heart disease
Conditions
Interventions
group C:None
the ulinastatin group(group U):Patients in group U were intravenously infused with ulinastatin (Techpool, Guangdong, China) at a rate of 10,000 U/ kg/hour for the first hour after anesthesia induction
the alveolar recruitment maneuver group(ARM, group A):In group A, immediately after the end of cardiopulmonary bypass, lung recruitment was achieved by sequential increases in PEEP in three steps from
the ulinastatin combined with alveolar recruitment maneuver group(group U+A):Patients in group U+A were intravenously infused with ulinastatin and alveolar recruitment maneuver.
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: American Society of Anesthesiologists (ASA) scores between class II and III pediatric patients undergoing correction of congenital heart disease whit right vertical infra-axillary thoracotomy under general anaesthesia gave written informed consent to participate in this randomized controlled study. Inclusion criteria were aged 1-6 year, and preoperative diagnosis of atrial septal defect (ASD), ventricular septal defect (VSD) and partial atrioventricular septal defects (PAVSD).
Exclusion criteria
Exclusion criteria: Exclusion criteria were refusal to give consent, BMI 35 kg/m2, significant cardiac dysfunction (left ventricular ejection fraction ,40%) , asthma requiring bronchodilator therapy, restrictive lung disease and emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CI;IL-2, IL-6, IL-8, IL-10 and TNF-a;respiratory index (RI);oxygenation index (OI);Mechanical ventilation time;Time of intensive care unit;Hospital stay;respiratory compliance; | — |
Countries
China
Contacts
Public ContactJun Ma
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed