Study for Exfoliated Tumor Cells (ETCs) from Broncho Alveolar Lavage Fluid (BALF) and Circulating Tumor Cells (CTCs) from Peripheral Blood from Patients with Pulmonary Nodules for the Diagnosis of Early Lung Cancer through Micropore-array Filtration versus Conventional ThinPrep Test (TCT)

Study for New Methods in Nanomedicine Diagnosis of Early Lung Cancer based on the Rare Exfoliated Tumor Cells (ETCs) from Broncho Alveolar Lavage Fluid (BALF)

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900023552

Enrollment

Unknown

Registered

2019-06-02

Start date

2019-06-01

Completion date

Unknown

Last updated

2021-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung cancer

Interventions

Gold Standard:The pathological diagnostic results of the resected nodule tissue

Index test:Hematoxylin-Eosin&#32

staining

&#32

Immunofluorescent&#32

Gene&#32

sequencing

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and older; 2. Patients with suspected pulmonary nodule; 3. Bronchial lavage undergoing for diagnostic purpose of lung cancer; 4. Informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients who are unwilling or contradict to have a bronchoscopy; 2. Patients with respiratory failure; 3. Patients with pregnancy.

Design outcomes

Primary

Measure	Time frame
The detection positive rate of exfoliated tumor cells (ETCs) from broncho alveolar lavage fluid with the micropore array filtratration;The detection positive rate of circulating tumor cells (CTCs) from peripheral blood with the micropore array filtration;The detection specificity of exfoliated tumor cells (ETCs) from broncho alveolar lavage fluid with the micropore array filtration;The detection specificity of circulating tumor cells (CTCs) from peripheral blood with the micropore array filtration;The detection positive rate of circulating tumor cells (CTCs) from peripheral blood with the conventional ThinPrep Test (TCT));The detection specificity of circulating tumor cells (CTCs) from peripheral blood with the conventional ThinPrep Test (TCT);	—

Measure

Time frame

The detection positive rate of exfoliated tumor cells (ETCs) from broncho alveolar lavage fluid with the micropore array filtratration;The detection positive rate of circulating tumor cells (CTCs) from peripheral blood with the micropore array filtration;The detection specificity of exfoliated tumor cells (ETCs) from broncho alveolar lavage fluid with the micropore array filtration;The detection specificity of circulating tumor cells (CTCs) from peripheral blood with the micropore array filtration;The detection positive rate of circulating tumor cells (CTCs) from peripheral blood with the conventional ThinPrep Test (TCT));The detection specificity of circulating tumor cells (CTCs) from peripheral blood with the conventional ThinPrep Test (TCT);

—

Secondary

Measure	Time frame
Gene and protein marker from ETCs, CTCs and resected nodule tissue;	—

Countries

China

Contacts

Public ContactWang Wei

Peking University

w.wang@pku.edu.cn+86 13910407960

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026