Pulmonary Hypertension
Conditions
Interventions
experimental group:Three cycles of lower limb ischemia (in excess of the 30mmhg pressure of the brachial artery) and 5 minutes of reperfusion were performed every day with an inflatable cuff.
control group:Using an inflatable cuff for three cycles of 5 minutes of lower limb compression (at 40mmhg pressure) and 5 minutes of no pressure binding.
Sponsors
Gansu Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Right cardiac catheterization for patients with mPAP >= 25 mmhg, PAWP 3wood units.
Exclusion criteria
Exclusion criteria: (1) Left heart disease-induced pulmonary hypertension, respiratory and / or hypoxia-induced pulmonary hypertension and unknown factor-induced pulmonary hypertension; (2) Patients with occlusive vasculitis or arteritis involving lower extremity vessels; (3) Patients with venous thrombosis of lower extremities; (4) The patients who cannot tolerate the treatment of lower limb ischemia (For example, people with severe disabilities, stress fractures in the near future, severe burns in the skin, rupture of the skin and so on.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six-minute walk distance;oxygen saturation of blood;Ejection fraction of left ventricle;Tricuspid annulus contraction displacement;pulmonary arterial systolic pressure;cardiac index;Cardiac output;Interleukin-1 ß;Interleukin-6;Interleukin-8;Interleukin-10;haemopoietin;serum creatinine;Troponin-t;Creatine kinase isoenzyme;Tumor necrosis factor- a;active oxygen;prostacyclin;cyclic guanosine monophosphate;;nitric oxide;nitrite;adenosin;angiogenic growth factor;endothelin-1;Human fatty acid binding protein;hemoglobin; | — |
Countries
China
Contacts
Public ContactYunshan Cao
Gansu Provincial People's Hospital
Outcome results
None listed