aplastic anemia,Refractory Cytopenia of Childhood
Conditions
Interventions
1:Fludarabine150 mg/m2 +Cyclophosphamide200 mg/kg+ Thymoglobuline10mg/kg
2:Fludarabine200 mg/m2 +Cyclophosphamide120 mg/kg+ Thymoglobuline10mg/kg+300cGy TBI
3:Fludarabine200 mg/m2 +Cyclophosphamide120 mg/kg+ Thymoglobuline10mg/kg+ Busulfan 8mg/kg
Sponsors
Shanghai Children's Medical Center affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Severe aplastic anemia,very severe aplastic anemia,transfusion denpendent non-severe aplastic anemia or refractory cytopenia of childhood; 2. Younger than 18 years old; 3. Sign the informed consent document.
Exclusion criteria
Exclusion criteria: 1. Congenital bone marrow failure; 2. Hypoplastic myelodysplastic syndrome with cytogenetic abnormality as Monosomy 7; 3. Severe organ dysfunction:Alanine transaminase (ALT) more than 3x upper limit of normal,Serum bilirubin greater than 2 x upper limit of normal,Creatinine Clearance less than 60 ml/min,Left ventricular ejection fraction less than 50%; 4. Active infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| failure free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| overall survival;Engraftment;incidence of acute graft versus host disease;incidence of chronic graft versus host disease; | — |
Countries
China
Contacts
Public ContactCHEN JING
Shanghai Children's Medical Center affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed