spontaneous abortion
Conditions
Interventions
Healthy control group:None
spontaneous abortion group:none
Sponsors
Nanjing Maternity and Child Health Care Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Spontaneous abortion group inclusion criteria: Diagnosed spontaneous abortion pregnant women according to Obstetrics and Gynecology (The ninth edition, 2018). Normal pregnancy group inclusion criteria: Pregnant women had no previous spontaneous abortion, stillbirth history. And there were no symptoms and signs of threatened abortion such as vaginal bleeding and abdominal pain during this pregnancy; and ultrasound confirmed that the embryo was developing normally. All pregnant women in two groups meet the following inclusion criteria: 1.Aged between 20 and 45 years. 2.Gestational weeks less than 28 weeks. 3.Signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients who had other high-risk factors which might relate with spontaneous abortion, including: (1) Karyotype abnormalities, single gene and/or polygenetic hereditary diseases; (2) Anatomical abnormalities of genital tract: any congenital anatomical abnormalities of uterus; intrauterine adhesions; myoma of uterus; endometrial polyps; (3) Endocrine abnormalities; (4) Autoimmune disorders; (5) Hypercoagulation state; (6) Negative RH blood groups; (7) Abnormal semen results of patients husband. 2.Patients with serious diseases; 3.Patients with administration of contraceptive pills; 4.Patients could not be followed-up of a long time or had poor compliance; 5.Patients with other factors that would affect the study result.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| miR-515-3p;miR-517a;miR-525-3p;miR-141;miR-200c;hCG;progesterone;Gestational age; | — |
Countries
China
Contacts
Public ContactZhong Tianying
Nanjing Maternity and Child Health Care Hospital
Outcome results
None listed