Childhood malignancy (leukemia, lymphoma, rhabdomyosarcoma, etc.)
Conditions
Interventions
Sponsors
Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1) Women aged 10-18; 2) identified as a child malignant tumor (rapid lymph, acute marrow, solid tumor, rhabdomyosarcoma, etc.); 3) receiving chemotherapy; 4) Development is in accordance with age; 5) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients with precocious puberty and gonadal dysplasia; 2) Patients with severe comorbidities who cannot tolerate chemotherapy; 3) Those who have a history of diabetes who are taking any hypoglycemic agents; 4) Those who have received chemotherapy and pelvic area radiotherapy before; 5) known to be allergic to metformin hydrochloride and its analogues; 6) Patients who are participating in or have participated in other clinical trials for the past 3 months; 7) Oral contraceptives or hormonal drugs during the trial; 8) Other patients identified by the investigator as unfit for the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-Mullerian hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| The quality of second sexual;sexual hormon+InhibinB;Bone age assessment;Safety assessment;menarche; | — |
Countries
China
Contacts
Public ContactShixuan Wang
Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed