breast cancer patients
Conditions
Interventions
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) Premenopausal women aged 18-45 years old; 2) Breast cancer staging: patients receiving adjuvant/neoadjuvant chemotherapy in stage I-IIIa; 3) Assessment of normal ovarian function before chemotherapy (regular menstruation or active 6 weeks before chemotherapy); 4) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Those who have received chemotherapy and pelvic area radiotherapy before; 2) Combine endocrine diseases (such as PCOS, hyperprolactinemia, hyperandremia, adrenal dysfunction, etc.) that affect ovarian function; 3) Combine cardiovascular, liver, kidney, infectious diseases, hematopoietic system and other serious diseases, with a history of lactic acidosis or high risk factors; 4) distant metastasis of breast cancer; 5) pregnant or lactating women; 6) A history of diabetes is currently taking any hypoglycemic agent; 7) known to be allergic to metformin hydrochloride and its analogues; 8) Patients who are participating in or have participated in other clinical trials in the past 3 months; 9) oral contraceptives or hormonal drugs during the trial; 10) Other patients identified by the investigator as unfit for the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Menstruation recovery rate;disease-free survival (DFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Sex hormones+AMH+InhibinB;5-year pregnancy outcome;Tumor prognosis;The quality of patient's life;Safety assessment; | — |
Countries
China
Contacts
Public ContactShixuan Wang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed