ovarian cancer patients
Conditions
Interventions
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 18-45 years old; 2) Pathological diagnosis is limited to unilateral ovarian epithelial cancer; malignant germ cell tumor (unlimited staging); IC stage stromal stromal cell tumor; 3) retain one or both sides or part of the ovaries; 4) Who receive chemotherapy; 5) Estimated survival period: more than 2 years; ECOG score is 0-1 points; 6) Normal ovarian function before chemotherapy (regular menstruation 2 months before chemotherapy); 7) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Those who have received chemotherapy and pelvic area radiotherapy before; 2) Combine endocrine diseases (such as PCOS, hyperprolactinemia, hyperandremia, adrenal dysfunction, etc.) that affect ovarian function; 3) Combine cardiovascular, liver, kidney, infectious diseases, hematopoietic system and other serious diseases, with a history of lactic acidosis or high risk factors; 4) pregnant or lactating women; 5) A history of diabetes is currently taking any hypoglycemic agent; 6) known to be allergic to metformin hydrochloride and its analogues; 7) Patients who are participating in or have participated in other clinical trials for the past 3 months; 8) Oral contraceptives or hormonal drugs during the trial; 9) Other patients identified by the investigator as unfit for the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Menstruation recovery rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sex hormones+AMH+InhibinB;5 years of pregnancy;Tumor prognosis;Patient’s life quality;Safety assessment; | — |
Countries
China
Contacts
Public ContactShixuan Wang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed