Cerebral Hemorrhage
Conditions
Interventions
Intensive antihypertensive treatment group:To reduce systolic blood pressure to 120-140mmHg by intravenous application of antihypertensive drugs.
Standard antihypertensive treatment group:To control systolic blood pressure to 140-180mm by intravenous application of placebo or antihypertensive drugs.
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years. 2. Arriving at hospital, being randomized and receiving intravenous antihypertension within 4.5 hours after ICH onset. 3. CT confirmed supratentorial parenchymal hematoma, and hematoma volume 8. 4. For patients who did not use antihypertensive drugs, SBP = 180mmHg after admission (before treatment with intravenous antihypertensive drugs, including pre-hospital treatment), and SBP did not spontaneously reduce to below 180mmHg during randomization. For subjects randomized after the start of intravenous antihypertensive drug management: SBP was =180 mmHg before treatment (including pre-hospital treatment), and SBP should be=140 mmHg when randomized. 5.The patient or legal representative signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Cerebral hemorrhage is caused by secondary factors such as known tumors, arteriovenous malformations, aneurysms, trauma, and clinically diagnosed amyloid angiopathy. 2. When the parenchymal hemorrhage extends to the ventricles, the blood completely fills one lateral ventricle or more than half of the two lateral ventricles. 3. Surgical treatment is planned within 24 hours. 4. Pregnancy or within 30 days of delivery. 5. Patients who have used anticoagulant drugs in the past 24 hours. 6. Disability caused by previous diseases(mRS>2). 7. Severe heart disease, liver disease, kidney disease (eGFR <30 ml/min) or malignancy, life expectancy <3 months. 8. Currently participating in other interventional clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the proportion of poor prognosis at 90 days;national institute of health stroke scale;Glasgow coma scale;blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| hematoma volume;edema volume;fasting blood glucose; | — |
Countries
China
Contacts
Public ContactLu Jingjing
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed