chronic atrophic gastritis with dysplasia
Conditions
Interventions
A:Weierkang
B:Weierkang and Folic acid
Sponsors
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: Referring to consensus on chronic gastritis in China(Shanghai, 2017), the patients were diagnosed as CAG , aged 20-70 years. 1. Gastroscopic examination or NBI combined with magnifying gastroscopy was performed within 2 months before enrollment, and the gastric mucosa was found to be granular, mucosal blood vessels were exposed, gray color was dark, and wrinkles were fine; 2. Biopsy tissue pathology showed mucosal inflammation, divided into three levels. Mild: inflammatory cell infiltration at the bottom of the pit; moderate: inflammatory cells infiltrated deep into the lamina propria; severe: inflammatory cells infiltrated deep into the mucosal muscle layer. Atrophic gastritis manifests itself, intrinsic gland atrophy: less than 1/3 is mild; 1/3 to 2/3 is moderate; reduction is >2/3 is severe. At the same time, the degree of intestinal metaplasia and dysplasia were observed.
Exclusion criteria
Exclusion criteria: 1. Combined with malignant tumor,espencially esophageal cancer and gastric cancer; ulcer, barretts esophagus or other upper GI diseases; 2. Acid inhibitors (H2 antagonists or proton pump inhibitors) promote power medicine (mosapride or domperidone, etc.) or gastric mucosa protectant for pury (teprenone, sucralfate, gefarnate, glutamine, rebamipide, bismuth, etc.) were taken two weeks before this trial; 3. Serious comorbidities of heart, lung, liver, kidney or blood system; 4. Female patients preparing for a baby, pregnant or lactating; 5. Dropping out of this trials before the end of treatment, or can't cooperate with researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total effective rate;The effective rate;The reverse rate; | — |
Countries
China
Contacts
Public ContactChen Shujie
Department of Gastroenterology, Sir Run Run Shaw Hospital
Outcome results
None listed