Chronic Rhinosinusitis
Conditions
Interventions
Nasal Drop group:Budesonide nasal spray 128ug BID and budesonide repulse nasal drop 1mg qd
Nasal Spray group:Budesonide nasal spray 128ug BID
Medrol group:Budesonide nasal spray 128ug BID and methylprednisolone 24mg QD
Sponsors
Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis of CRSwNP is based on the standard croteria in the European Position Paper of Rhinosinusitis and Nasal Polyps guideline; 2. Aged 18-75 years; 3. Chinese nationality.
Exclusion criteria
Exclusion criteria: 1. Patients who use systemic glucocorticoids or antibiotics 1 month before randomization or use local glucocorticoids 2 weeks before randomization; 2. Patients with upper respiratory tract infection or asthma exacerbation 2 weeks before randomization; 3. Patients in pregnancy and lactation; 4. Patients with sever underlying diseases or with systemic diseases which has to take glucocorticoids continually; 5. Patients who allergic to glucocorticoids; 6. Patients who are participated in clinical trials for nearly 30 days; 7. Patients who cannot cooperate with investigation; 8. Patients with Sinus neoplasms, fungal sinusitis, posterior nasal polyps and other nasal disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total nasal symptom score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sinonasal-Outcome Test 22;Endoscopic score;Blood eosinophil count;Tissue eosinophil count; | — |
Countries
China
Contacts
Public ContactYinyan Lai
Outcome results
None listed