Hepatitis B related fibrosis
Conditions
Interventions
Control group:None
Intervention group:Berberine
Sponsors
Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18 to 70 years, male or female. 2) Patients with HBsAg positive for more than 6 months, and currently HBsAg positive and / or serum HBV DNA = 500 copies / ml; 3)Regular use of antiviral drugs for more than a year 4) Real-time two-dimensional shear wave elastography Liver fibrosis stage F2-F4 was evaluated by liver stiffness (LSM) of 2D SWE.
Exclusion criteria
Exclusion criteria: 1) Patients who are unable or unwilling to sign an informed consent form; 2) Patients with hepatitis C, alcohol and nonalcoholic fatty liver disease, autoimmune liver disease, hereditary metabolic liver disease, various biliary system diseases, hepatobiliary parasitic diseases; 3) There are other systems with serious chronic diseases,including heart, kidney function and other organ dysfunction or history of malignant tumors; 4) Berberine drug contraindications: patients with hemolytic anemia and patients with glucose-6-phosphate dehydrogenase deficiency; 5) Patients with severe hepatorenal syndrome; 6) Pregnant or lactating women or patients who have a pregnancy plan and are unwilling to contraception during the study period; 7) Patients who can not use drugs according to regulations, poor compliance; 8) Patients who have been participating in other drug clinical trials for nearly half a year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| liver stiffness;Assessment of liver tissue inflammation;Evaluation of liver fibrosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Child-Pugh;Meld; | — |
Countries
China
Contacts
Public ContactXiaoying Wu
Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed