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Intermittent pulse stimulation (ITBs) combined with working memory training to improve cognitive function in schizophrenia: a randomized controlled study

Intermittent pulse stimulation (ITBs) combined with working memory training to improve cognitive function in schizophrenia: a randomized controlled study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900023405
Enrollment
Unknown
Registered
2019-05-25
Start date
2019-06-01
Completion date
Unknown
Last updated
2020-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

schizophrenia

Interventions

1:iTBS+WMT
2:iTBS+SRT
3:sham-iTBS+WMT
4:sham-iTBS+SRT

Sponsors

Beijing Huilongguan Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Comply with the Diagnostic Criteria for Mental Disorders Diagnostic Statistics Manual (DSM-IV) for schizophrenia; 2. PANSS positive amount form item score <5 points, positive scale total score <22 points; 3. Aged 18-45 Years, received more than 5 years of formal education; 4. patients volunteered to participate in the study, and signed informed consent; 5. the past month and estimated the next month the drug types, doses do not need to be adjusted; 6. the existence of cognitive damage: the number down Back breadth = <6; 7. right hand, using the Edinburgh hand evaluation scale to determine.

Exclusion criteria

Exclusion criteria: 1, with mental retardation or brain organic disease; 2, severe decline or impulsive excitement; 3, accompanied by severe depression, anxiety and substance abuse; 4, there are hearing or / visual perception disorders; 5, serious Physical illness or side effects of drugs, unable to carry out cognitive training; 6, pregnant or lactating women; 7, metal foreign bodies in the body should not be MRI scan.

Design outcomes

Primary

MeasureTime frame
MATRICS Consensus Cognitive Battery, MCCB;

Secondary

MeasureTime frame
Positive And Negative Syndrome Scale, PANSS;Brief Negative Symptom Scale, BNSS;Personal and Social Performance Scale, PSP;Schizophrenia Quality Of Life Scale, SQOL;Self-Esteem Scale, SES;Temporal Experience of Pleasure Scale, TEPS;Morphological structure parameters of gray matter and white matter;Functional plasticity parameters;

Countries

China

Contacts

Public ContactShuping Tan

Beijing Huilongguan Hospital

shupingtan@126.com+86 010-83024485

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 26, 2026