Patients under general anesthesia
Conditions
Interventions
experimental group :Desflurane combined with dexmedetomidine
control group:Desflurane
Sponsors
The First People’s Hospital of Shuangliu District, Chengdu
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. For patients undergoing elective general anesthesia for 1 to 2 hours, endotracheal catheter should be removed after surgery; 2. Aged over 60 years; 3. ASA classification: level I~ II; 4. MMSE score is greater than 24; 5. Subjects will sign the informed consent voluntarily;
Exclusion criteria
Exclusion criteria: 1. Allergic or abnormal reaction to desflurane; 2. Allergic or abnormal reaction to dexmedetomidine; 3. Preoperative patients with cognitive dysfunction and hearing impairment; 4. A history of long-term use of narcotic analgesics, sedatives and antidepressants; 5. Body mass index (BMI) 35kg/m2; 6. Preoperative acute infection; 7. Patients who cannot be followed up; 8. Participated in other clinical trials within three months before the included study; 9. With history of serious cardiovascular diseases (e.g., coronary heart disease or congenital heart disease, grade 3 or above cardiac function); 10. With history of alcohol and drug use; 11. Suffering from mental disorders, unable to communicate normally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE score before and 24 hours after anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood routine examination;Blood IL-6 level 24 h after surgery;Blood TNFa level 24 h after surgery;Demographic data; | — |
Countries
China
Contacts
Public ContactLin Hui
The First People’s Hospital of Shuangliu District, Chengdu
Outcome results
None listed