A Neonate Cohort Study of p.V37I Mutations in GJB2 Cause Children's Hearing Loss

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1900023367

Enrollment

Unknown

Registered

2019-05-24

Start date

2019-05-27

Completion date

Unknown

Last updated

2020-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deafness

Interventions

Non-exposed Group:no intervention

Exposed Group:no intervention

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Neonatal gene screening for homozygous mutation carriers of GJB2 gene p.V37I and contemporaneous wild type subjects of GJB2 gene p.V37I,the diagnosis of GJB2 gene p.V37I mutation is confirmed by gold standard test (Sanger sequencing); the subjects fully understand and then signed an informed consent form(ICF).

Exclusion criteria

Exclusion criteria: The GJB2 gene homozygous p.V37I mutation carriers and contemporaneous random sample of wild type GJB2 gene p.V37I could not be followed up as required.

Design outcomes

Primary

Measure	Time frame
Questionnaire Surveys;blood and urine routine, Blood Biochemistry;Audition Test;	—

Countries

China

Contacts

Public ContactWu Hao

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine

wuhao622@sina.cn+86 13601621152

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026