melasma
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for melasma; 2. Non-menopausal women who are older than 18 years old; 3. The subject has not used other ecchymoses, whitening products or other treatment methods 1 month before the study; 4. Do not use other ecchymoses, whitening products and other treatment methods throughout the study period; 5. Sign the informed consent form and agree to complete the observation of this clinical trial.
Exclusion criteria
Exclusion criteria: 1. Pigmentation caused by other diseases; 2. Received other treatments or treatments related to this disease within 3 months; 3. Pregnant or lactating women; 4. Use drugs that affect endocrine factors within half a year; 5. Recently taken hormonal contraceptives; 6. Patients with severe primary organ, endocrine disease and mental illness; 7. Laser treatment or dermabrasion within 9 months; 8. The main activity area is outdoor; 9. Patients have broken, impregnated, erosion and other skin lesions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified Melasma area severity index(mMASI);VISIA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physicians Global Assessment (PGA);MELASQOL scale; | — |
Countries
China
Contacts
Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University