none
Conditions
Interventions
1:intranasal Dexm+Buccal MDZ
2:Buccal MDZ+Dexm
Sponsors
Guangzhou Women and Children's Medical Centre
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: 1 Outpatients or inpatients, scheduled to receive sedation for MRI examination. 2 ASA physical status I-III. 3 The subjects must be 3 months to 36 months(inclusive of the 36th month) of age. 4 The scanning time of MRI examination is within 1 hour. 5 The subjects legally authorized representative has given written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1 The subject is allergic to or has a contraindication to any of the drugs or masking flavored syrup used in the study. 2 The subject has cardiac conduction system disease (e.g. 2nd degree AV block). 3 The subject has received digoxin or beta-adrenergic antagonist on the day of the study. 4 The subject has Trisomy 21 (exaggerated risk of bradycardia). 5 The subject has severe coarctation of the aorta (risk of exaggerated vasoconstriction). 6 Patients with acute nasal or respiratory symptoms on the day of the study (potential interference with intranasal absorption). 7 The subject has received a dose of any other sedative within 48 hours. 8 The subject has BMI>24(risk of respiratory depression).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sedation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;Heart rate;adverse reaction; | — |
Countries
United States
Contacts
Public ContactBilian Li
Guangzhou Women and Children's Medical Centre
Outcome results
None listed