Cerebral small vessel disease
Conditions
Interventions
Vascular cognitive impairment caused by cerebral small vessel disease:no intervention
Vascular cognitive impairment caused by non-cerebral small vessel disease:no intervention
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. With or without a clear history of stroke; 2. The incidence of cognitive impairment is relatively slow; 3, imaging shows multiple lacunar infarction or extensive white matter lesions, or both coexist; 4. MMSE score < 20 points or MoCA score < 26 points; 5, Hamilton Depression Scale (HAMD) score <10 points; 6. Understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have a history of anxiety, depression or other psychiatric history; 2. The patient did not report a history of anxiety, depression, or other mental illness, but was diagnosed by the Hamilton Anxiety Scale (HA-MA) and the Hamilton Depression Scale (HRSD-17); 3. A history of clear non-vascular cognitive dysfunction; 4, Severe aphasia, can not cooperate with psychological measurers; 5, Severe cardiopulmonary dysfunction, can not complete the psychological measurement; 6. Those who do not cooperate; 7. Have participated in other clinical trials within 30 days prior to the date of informed consent, or are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum 25-hydroxyvitamin D; | — |
Secondary
| Measure | Time frame |
|---|---|
| cognitive function score; | — |
Countries
China
Contacts
Public ContactLifeng Lin
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed