Moderate and Severe Cancer Pain
Conditions
Interventions
1:Hydromorphone
2:Morphine
Sponsors
Pain Management Department of West China Hospital Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Aged =18 years; 2) The patient with VAS=4 or breakthrough pain>3 times/day; 3) Oral equivalent morphine dose=60mg/d,unsatisfactory pain control; 4) The patient who can describe symptoms objectively and without serious infection.respiratory insufficiency,etc; 5) The patient without a history of drug abuse; 6) Non-pregnant&lactating women;the patient without a pregnancy plan within 1 month after the trial(including male); 7) The patient who did not participate in the drug test(including this drug) within 3 months before the test; 8) The patient volunteered to participate in this study.
Exclusion criteria
Exclusion criteria: 1) The patient who can not use subcutaneous administration; 2) Respiratory depression has shown purpura; 3) Allergic person,and the patient who suffered from allergic diseases or allergic to drugs similar in structure to the study drug; 4) Cognitive dysfunction; 5) The patient without morphine contraindications;the morphine contraindications such as Digestive tract perforation.Intestinal obstruction,etc; 6) Increased intracranial pressure and brain injury; 7) Bronchial Asthma; 8) Decompensated pulmonary heart disease; 9) Hypothyroidism; 10) Cortical insufficiency; 11) Prostatic hypertrophy,Dying dysuria; 12) Severe liver dysfunction; 13) Uncorrected shock.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain relief rate;VAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number and extent of breakthrough pain;BPI;The satisfaction assessment of patient and medical staff; | — |
Countries
China
Contacts
Public ContactHui Liu
Pain Management Department of West China Hospital Sichuan University
Outcome results
None listed