Repeated embryo implantation disorder
Conditions
Interventions
Group A:Acupuncture+Conventional treatment of IVF
Group B:Chinese medicine+Conventional treatment of IVF
Group C:Acupuncture+Chinese medicine+Conventional treatment of IVF
Group D:Chinese medicine placebo+Conventional treatment of IVF
Sponsors
Affiliated Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
Female
Age
18 Years to 37 Years
Inclusion criteria
Inclusion criteria: 1) Married women, aged older than 18 years and younger than 37 years; 2) Transvaginal ultrasound assessment of normal uterine cavity morphology; 3) Failure of embryo transfer (IVF/ICSI/FET) with 2 or more consecutive cycles, or failure to accumulate =4 cleavage stage embryos or 2 blastocysts; 4) Frozen embryo transfer, or who are undergoing further IVF/ICSI cycles (fresh cycle).
Exclusion criteria
Exclusion criteria: 1) Those who have received acupuncture treatment or oral Chinese medicine in the past 3 months; 2) Accepting eggs; 3) There are hysteroscopy within 2 months; 4) Ultrasound diagnosis of uterine submucosal fibroids, or uterine fibroids in the uterine wall to distort the uterine cavity; 5) Untreated patients with tubal effusion; 6) The body mass index (BMI) is higher than 30 kg/m; 7) Combined with hypothyroidism or hyperthyroidism, poor control of thyroid hormone levels in the past 3 months; 8) A history of pituitary tumors, currently associated with hyperprolactinemia; 9) Definitively diagnosed autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, or the use of low molecular weight heparin, aspirin, immunosuppressive agents, etc.; 10) Atosiban is used in the transplant cycle; 11) Those who do not agree to sign the informed consent of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate;endometial thickness;Total dose of ovulatory drugs;Rretrieved oocytes;Rretrieved mature oocytes;Estradiol levels;Progesterone levels;Human chorionic gonadotropin;Inflammatory markers;D-dimer;SF-36;Chinese Quality of Life Instrument.;Zung-SAS and Zung-SDS;MASS; | — |
Countries
China
Contacts
Public ContactMingmin Zhang
Affiliated Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
Outcome results
None listed