Practical, randomized, controlled, multi-center clinical study for Qingre Jiedu Mixture in the treatment of children with viral encephalitis and meningitis

TCM early clinical treatment system and pre-plan study for acute infectious diseases - Optimization of diagnosis and treatment pre-plan and treatment plan for encephalitis and meningitis syndrome by integrated Chinese and western medicine.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1900023274

Enrollment

Unknown

Registered

2019-05-20

Start date

2019-06-01

Completion date

Unknown

Last updated

2019-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

viral encephalitis and meningitis

Interventions

Treatment group:basic treatment + Qingre Jiedu Mixture

Control group: basic treatment

Eligibility

Sex/Gender

All

Age

1 Years to 14 Years

Inclusion criteria

Inclusion criteria: (1) Comply with the diagnostic criteria of viral encephalitis and meningitis. (2) Comply with the diagnosis of the syndrome warm heat intermingled with dampness. Primary symptoms: fever, lack of energy, lethargy, headache, aversion to cold or not, dry throat, thirst, vomiting, or visible skin rash, frequent convulsions, reversal cold of limbs. Secondary symptoms: red tongue, yellowish tongue fur or greasy, surging and rapid pulse, or upset, disturbing, delirious speech. (3) Hospitalized patients. (4) The course of disease is = 7 days. (5) Aged 1-14 years. (6) Voluntary participation in the study, the patients or their guardian signed an informed consent form.

Exclusion criteria

Exclusion criteria: (1) Combined with other serious systemic diseases (such as cardiovascular and cerebrovascular diseases) and mentally ill patients. (2) Patients with intracranial space-occupying lesions. (3) Patients with severe complications such as septic shock and DIC. (4) Due to severe gastrointestinal bleeding, pancreatitis and other serious conditions, the patients who cannot be administered by the gastrointestinal tract after doctors judging. (5) Affecting data collection due to various factors. (6) Anti-HIV and / or syphilis antibody positive. (7) History of allergies to traditional Chinese medicine. (8) Participate in other clinical trials or research.

Design outcomes

Primary

Measure	Time frame
Cure rate;	—

Secondary

Measure	Time frame
Case fatality rate.;GCS score;mRS score;Complication rate;Duration of body temperature returns to normal;Coma duration;Duration of convulsion relief;Antibiotic use rate;Incidence of gastrointestinal dysfunction;ICU occupancy rate;ICU occupancy duration;TCM symptom score;Duration of mechanical ventilation;Disability rate;Health economics evaluation;	—

Countries

China

Contacts

Public ContactLi Ang

Beijing Ditan Hospital, Capital Medical University

snowpine12@sina.com+86 15901033321

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026